Study on chemical constituents from Ixeris dentata

Ixeris dentata (Thunb. ex Thunb.) Nakai (family Asteraceae) a plant widely distributed in Viet Nam, is perennial herb that grows to height of 0.5 m. It has been used as medicinal medicine since ancient times for the treatment calculi, dyspepsia, indigestion, pneumonia, hepatitis, contusion, and tumors Northeast Asia. The biological activities this have shown be neuroprotective, anti-mutagenic, anti-hyperlipidemic, anti-inflammatory, anti-allergic, anti-proliferative activities. also composed aliphatics, triterpenoids, sesquiterpene, glycosides. However, research on phytochemistry yet conducted Nam. In study, five phenolics including chlorogenic acid (1), 3,5-di-O-caffeoylquinic (2), 4,5-di-O-caffeoylquinic (3), citrusin C (4), 4-allyl-2,6-dimethoxyphenol O-β-D-glupyranoside (5), two sesquiterpene lactones, 8-epidesacylcynaropicrin glucoside (6) ixerisoside A (7) were isolated from methanol extract leaves using combined chromatographic methods. Their chemical structures determined by analysis MS, NMR spectra data well comparison with those reported literature.